CHEMICAL NAME:
4-Hydroxyphenyl-alpha-D-glucopyranoside; Hydroquinone-O-ALPHA-D-glucopyranoside
CAS: 84380-01-8 C12H16O7
Alpha-Arbutin is the more effective, faster and safer approach to skin lightening. It lightens the color of the skin more efficiently and effectively than do existing single components
PROPERTIES:
Alpha-arbutin blocks epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. It acts faster and more efficient than do existing single components.
FUCNTION:
*Promotes lightening and an even skin tone on all skin types.
*Minimizes liver spots.
*Can reduce the degree of skin tanning after UV exposure.
COSMETIC APPLICATION:
*All degrees of skin lightening.
FORMULATIONS:
Alpha-arbutin is a water soluble, crystalline, white powder which is easily incorporated into the water phase of cosmetic formulations. Alpha-arbutin is stable against hydrolysis as tested in the pH range from 3.5 to 6.5.
SUGGESTED CONCENTRATION
0.2% when formulated with an exfoliant or penetration enhancer, otherwise up to 2%.
IN-VITRO TEST:
Alpha-arbutin exhibits impressive in-vitro tyrosinase inhibition on human cell lysate (IC50 = 1.0 mMol) as compared to Beta-Arbutin (IC50 = 9.0 mMol).
MAIN SPECIFICATIONS:
INCI Name | : | ALPHA-ARBUTIN |
CAS No. | : | 84380-01-8 |
EINECS No. | : | 283-934-3 |
Appearance | : | White crystals or crystalline powder |
Identification | : | IR |
pH | : | 5.0 - 7.0 |
Melting rang | : | 202°C-210°C |
Specific rotation[a]20D | : | +175°~+185° |
Loss on drying (%) | : | ≤1.0 |
Clarity of water solution | : | Clear, T430nm≥95% |
Hydroquinone | : | ≤10ppm |
Heavy metals | : | ≤10ppm |
Arsenic | : | ≤2 ppm |
Ignition residue (%) | : | ≤0.5 |
Assay (%,HPLC) | : | ≥99.0 |
Aerobic Bacterial | : | ≤1000 CFU/g |
Molds & Yeast Count | : | ≤100 CFU/g |
Fecal Coliforms | : | Negative |
Pseudomonas Aeruginosa | : | Negative |
Staphylococcus Aureus | : | Negative |
EFFICACY OF ALPHA-ARBUTIN
FUNCTION:
• Promotes lightening and an even skin tone on all skin types.
• Minimizes liver spots.
• Can reduce the degree of skin tanning after UV exposure.
PROPERTIES:
ALPHA-ARBUTIN blocks epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa.
INHIBITION OF TYROSINASE IN VITRO
Alpha-arbutin shows impressive in-vitro tyrosinase inhibition on human cell lysates compared to ß-Arbutin.
ß-Arbutin: IC50 = 9.0 mMol Alpha-arbutin: IC50 = 1.0 mMol
SHORT-TERM IN VIVO SKIN-LIGHTENING STUDY
A skin lightening study on 80 Chinese descent women demonstrated that an emulsion containing 1% ALPHA-ARBUTIN results in a faster and more pronounced skin lightening effect after 1 month when compared with other commonly used mono-substances at 1 % each.
Figure 2: The classification of lightening mono-substances according to the magnitude of their specific effect after 1 month.
IN VIVO LIVER SPOTS EFFICACY STUDY
ALPHA-ARBUTIN (2%) in a cream formulation shows liver spot improving efficacy after 3 months.
Figure 3: Satisfaction quotients relating to the evaluation of the liver spot reduction.
IN–VIVO TANNING INHIBITING EFFECT AFTER UV EXPOSURE
In a further in–vivo study using 0.5% ALPHA-ARBUTIN in a cream formulation a tanning inhibiting effect after UV exposure has been shown.
Figure 4: Skin tanning prevention after UV exposure.
Documentation: