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INCI Name:Quaternium-73


-4-methyl thiazolium iodide; Pionin; Bioxyne


皮傲宁;感光素201;感光素201号;Kankohso 201; Pionin;

Photosensitizing Dye No.201

日文名称:クオタニウム-73; ピオニン
韩文名称:쿼터늄-73, 감광소201호
CAS No.:15763-48-1
EINESC/ELINCS No.:239-852-5
Molecular Formula:C23H39IN2S2





      Quaternium-73 shows extremely strong antibacterial activity at very low concentration. It damage the 

      microorganisms by causing collapse of cell membrane and cell wall and intracellular degradation.

      Quaternium-73 is similar to cyanine dyes. Even a single Quaternium-73 molecule also has

      anti-bacterial activity, which is the reason why Quaternium-73 is still efficient even with an extremely

      low  dose.

1.1  Fast and deep effect on anti-acne

       Quaternium-73 has an excellent effect on Propionibacterium acnes. It is commonly used in Japanese

        over-the-counter (OTC) as an anti-acne ingredient. Clinical research shows that it has a MIC= 0.00002%

        for acne bacilli, and the rash can be reduced by 50% after two weeks of use.


Clinical Test: Within two weeks, it reduced 50% spots

Testingprogram: Carry out test in 38 testees with acne problems

Method: Wash face 3 times every day withemulsion containing 0.001% of Quaternium-73 and smears twice a week with creamcontaining 0.005% of Quaternium-73.

Anti-acne, whitening, anti-freckle

1.2  Bactericidal activity

       The Quaternium-73’s bactericidal ability allows it to be used as a preservative. In vitro test data shows that

        in term of anti-bacteria and anti-fungi of various kinds, Quaternium-73 is more effective than paraben

        methyl ester. Therefore, just adding a small amount of paraben in the formulation containing

        Quaternium-73 is enough to achieve  an antibacterial effect.

                    MIC (%)
                MIC (%)
Escherichia coli
                 0.125-0.4                 0.005
Pseudomonas                 0.1-0.4                 >0.01
Staphylococcus                 0.16-0.4                0.005
Candida                      0.1                0.001
Aspergillus                 0.08-0.27                0.005

 Quaternium-73 can be used
alone (see the picture below, 

the number of E.coli contained in 0.002% quaternium-73)

Quaternium-73 can compensate

for the methylparaben (Adding

0.002% quaternium-73 can lead to an increase of anti-E.Coli activity of
0.005% methylparaben)

When mixed with polyols,

Quaternium-73 can completely
replace parabens as a preservative

1.3    Inhibits bacteria and fungi with an extremely low dose of use ( In vitro test )

         In vitro test (see table below, agar plate dilution) proves that the extremely low dose of use of 

         Quaternium-73 can also inhibit a wide range of bacteria and fungi. The lowest concentration of

         Quaternium-73 used to inhibit bacterial growth is called the Minimum Inhibitory Concentration (MIC).

          Bacterial names                           MIC %                    Fungi names                                 MIC %

           Liquid achromobacter sp               0.001                        Absidia orchidis                             0.0001

   Enterobacteriaceae                          0.01                          Tinea capitis fungus                      0.001
           Botulinum toxin                               0.005                        Black aspergillus                           0.005
           Escherichia coli                                0.01                           Aspergillus flavus                          0.0005
           Brown flavobacterium                    0.001                         Candida albicans                           0.001
           Proteusbacillus vulgaris                 0.001                         Epidermophyton floccosum       0.0001
           Pseudomonas aeruginosa              0.1                              Gypsum-like microsporum         0.0001
           Salmonella enteritidis                     0.005                        Soft rot rhizopus nigricans          0.001
           Staphylococcus aureus                   0.0005                      Saccharomyces sake                     0.001
           Staphylococcus citrate                    0.001                         Zygosaccharomyces                     0.0005


          In vitro test indicatesthat:

   0.000003% Quaternium-73can suppress 50% melanin formation

   0.00001% Quaternium-73can suppress 83% melanin formation.

   In contrast, 0.07% kojicacid can inhibit 100% melanin formation.


         Human body patch test ( human body, 0.2%, 48  hours ): negative
         Initial skin irritation ( rabbit, 0.2%, 24  hours ): negative
         Sustained skin irritation ( rabbit, 0.01%, 90  day ):negative
         Eye irritation ( rabbit, 0.0007%, 24  hour ): negative
         Skin sensitization ( Guinea pig, 0.2%, maximum test ):  negative
         Phototoxicity ( rabbit, 0.2%): negative
         Photosensitization ( Guinea Pig, 0.2%, Adjuvant-Strip Method ): negative
         Induced gene mutation (10μg, Ames test, ±S9 mix): negative
         Acute Toxicity LD 50 ( mouse ):325 mg/kg; LD50 oral rat: 460mg/kg



       Recommended dosage          0.001-0.005%

       Stable pH            5.5-8.0

   Good thermal stability   Up to 90ºC

  Solubility            Soluble in butylene glycol, propylene glycol, ethanol, 1,2– pentanediol. 
                                                                 Slightly soluble in water (0.6068mg/L @ 25°C (est)).

  Operation guide           It is recommended to pre-dissolve quaternium-73 in butylene glycol, propylene

                                                                glycol, or 1,2– pentanediol before adding. The dissolution can be accelerated by the aid

                                                                of boiling water bath.

  Photostability       Unstable; cosmetic products containing quaternium-73 need to be canned in opaque



       Quaternium-73 can be used in Cleaning products (facial cleanser, shampoo); Acne products, Oily skin care

        products; Whitening products; Synergist as preservative


    Compliant with Japanese Quasi Drugs to be used in anti-acne products; China Compliant


      Stored in a cool, dry, dark place.

      Special care is taken to prevent the powder from diffusing into the air. Wear a mask to avoid inhaling powder.

      After use please wash your body, hands, mouth and face thoroughly.


        Appearance              :    Light to yellow crystalline powder

        Purity (HPLC)         :    ≥99.0%

        Melting range          :    224-228ºC

        Loss on drying         :    ≤0.5%

        Heavy metals(Pb)   :    ≤10ppm

        Bacteria                    :   <500cfu/g

        Mold and yeast        :   <100cfu/g

        Escerichia coli         :    Negative


Quaternium-73 brochure.pdf

Quaternium-73 formulation.pdf

msds Quaternium-73.pdf

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