INCI Name : Nonapeptide-1
Synonyms : L-Methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-L-valinamide;
Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2
中文名称 : 九肽-1；抑黑素；melanostatine-5;
L-蛋氨酰-L-脯氨酰-D-苯丙氨酰-L-精氨酰-D-色氨酰-L-苯丙氨酰-L-赖氨酰-L-脯氨酰-L-缬氨酰胺
日文名 : ノナペプチド－１
한글 이름 : 노나펩타이드-1
CAS No. : 121062-08-6
Molecular Formula : C61H87N15O9S
Molecular weight : 1206.50
Sequence : Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val
Structure:
Nonapeptide-1
Specifications
1. White powder : purity 95%min.
2. Nonapeptide 1 solution : 100ppm min.
Functions
1. Inhibit melanin synthesis by interfering with the action of tyrosinase in melanocytes. Reduce hyperpigmentation and lighten darker areas that have been damaged by the sun and certain diseases.
2. Interfer with melanocyte stimulating hormone (MSH). MSH increases during pregnancy, as a result of certain medical conditions (e.g. diabetes, Addison’s disease), and as a result of excessive sun exposure.
3. Nonapeptide-1, at a concentration of 200 ug/mL, is capable of fully inhibiting the synthesis of melanin in fungi.
4. At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can reduce the melanin content of melanocytes by 27-43%
Remarks: for R&D purpose only.
Documentation: