Kojic Acid Dipalmitate
Stable alternative to kojic acid
Chemical Name /Synonyms
2-palmitoyloxymethyl-5-palmitoyloxy- γ- pyrone;
Hexadecanoic acid, 4-oxo-6-[[(1-oxohexadecyl)oxy]methyl]-4H-pyran-3-yl ester; KAD
Kojic dipalmitate is more efficacious than kojic acid in inhibiting the activity of tyrosinase present in human skin so as to inhibit the melanin formation and produce excellent effects in whitening skin and in anti-suntan.
Solubility and skin absorbance
Kojic acid dipalmitate is oil soluble and is more easily absorbed into skin when it is incorporated into a cream as compared with kojic acid
Kojic Acid Dipalmitate
Compatible with almost all cosmetic ingredients, especially advantageous for use in combination with sunscreens
may not be compatible with some organic sunscreens and preservatives due to potential hydrogen bonding,
Unstable to light
Stable. A cream containing 1% KAD found no color change when kept at 45°C for 4 weeks
Especially unstable above 40°C. A cream containing 1% Kojic acid become deep yellowish brown when kept at 45°C for 4 weeks
Stable between 3 and 10
Unstable when pH exceed 7
Not complex with metals
Chelate with metal ions ( e.g. iron) and color changes occur.
No color change occur
Easily become yellow or brown.
Inhibit tyrosinase and melanin formation, ameliorate dermal pigmentation. Provide excellent effects in even toning skin, fighting age spots, pregnancy marks, freckles as well as general pigmentation disorders.
Body/facial care toners, anti-aging preparations, sun protection, after-sun & self-tanning, skin whitening/lightening, treatment for a variety of skin hyperpigmentation conditions or disorders, e.g. solar lentigenes, melasma, chloasma, scars, freckles, age pigment and other local hyperpigmented regions of the skin
Use Level: 1 to 5%
Store in a cool and dry place. Keep away from direct strong light and heat.
White to pale yellow powdery crystals
Free kojic acid
KAD is difficult to incorporate into the formulation, and it easily precipitates in the form of crystals. To solve this problem, it is suggested that isopropyl palmitate or isopropyl myristate be added to the oil phase, and heat the oil phase to 80℃ and keep at this temperature for about 5 minutes so that KAD completely dissolved, then add the oil phase to water phase for emulsification at the same temperature for 10 minutes or so. Generally, pH in final product is generally around 5.0—8.0.
Unlike Kojic Acid, which may not be compatible with some organic sunscreens and preservatives due to potential hydrogen bonding, Kojic Dipalmitate is compatible with virtually all ingredients and is especially advantageous for use in combination with sunscreens.